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Each 100g Gel or Solution contains 25mg Vitamin A Acid (Tretinoin). USE IN PREGNANCY: It should not be used in pregnancy, unless the doctor is consulted.

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Topical retinoids during pregnancy Résumé / Abstract. New cases of birth defects were subsequently reported in children exposed in utero to topical tretinoin.

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Tretinoin and isotretinoin are. effect of either an excess or a deficiency of vitamin A. Systemic retinoids are highly teratogenic especially early in pregnancy.